Anesthetic Tetracaine HCl CAS 136-47-0

Payment Type: L/C,T/T,D/P,Paypal,Money Gram,Western Union
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Min. Order: 10 Gram
Delivery Time: 7 Days

Basic Info

Model No.: TF-2106

Type: Synthesis Material Intermediates

Appearance: Powder

Quality: Technical

Colour: White

Additional Info

Packaging: As Buyer's Request

Productivity: 100Ton

Brand: Tianfu

Transportation: Ocean,Land,Air,DHL,TNT

Place of Origin: China

Supply Ability: 50Ton

Certificate: ISO

Port: Shanghai port,Qingdao port

Product Description

product name: tetracaine hcl

synonyms:tetracaine hydrochloride ,2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; amethocaine hydrochloride

cas : 136-47-0

molecular formula: c15h25cln2o2
molecular weight: 300.82
einecs: 205-248-5
appearance: fine white crystalline and odorless powder
melting point: 145~150 degree
assay: 99%
grade: pharmaceutical grade
usage: local anesthetic; mainly used in mucosa anesthetic. the function is stronger than procaine .



product description:

1. tetracaine hcl is synthesized from 4-butylaminobenzoic acid. the ethyl ester is formed through an acid-catalyzed esterification reaction. base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.


2. tetracaine is the t in tac, a mixture of 5 to 12 per cent tetracaine, 5? (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.


3. it is on the world health organization's list of essential medicines, a list of the most important medication needed in a basic health system.a systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for iv cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt cannulations.






specifications:



items

quality standards

results

description

white or almost white crystalline powder

white crystalline powder

solubility

matching with the working standard

complies


identification

a.by ir, to match with working standard

complies

b: to 10ml of solution s add 1ml of ammonium thiocyanate solution r.a white,crystalline precipitate is formed which,after recrystallisation from water r and drying at 80ºc for 2h,melts at about 131ºc


complies

c. to about 5mg add 0.5ml of fuming nitric acid r .evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone r.add 1ml of 0.1m alcoholic potassium hydroxide.a violet colour develops

complies


d. solution s gives reaction of chlorides.

complies

ph

4.5~6.5

5.78

residual solvents

conform to standard

complies

claruty

solution should be clear

complies

related substances

conform to standard

complies

heavy metals

≤10ppm

<10ppm

loss on drying

≤1.0%

0.87%

resiue on ignition

≤0.1%

0.05%

melting range

148ºc

147.5ºc~150.8ºc

assay(*)

99%~101.0%

100.40%

conclusion

the sample complies with specification of ep8



applications:

1.tetracaine (inn, also known as amethocaine; trade name pontocaine. ametop and dicaine) is a potent local anesthetic of the ester group. it is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.


2.in biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. tetracaine is an allosteric blocker of channel function. at low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

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